Pueraria Mirifica

Pueraria mirifica is Thailand’s endemic species found mainly in the northern and western part of Thailand and has local name as White Kwao Krua. The Thai vine herbal plant is grown in association with the moderate-size trees ranking from timber wood to bamboo in the deciduous rain forest. The enlarge underground tuber accumulate “phytoestrogens” comprising isoflavone. The compounds that make Pueraria mirifica different from any other phytoestrogen- containing plants in the Family Leguminosae are Miroestrol and Deoxymiroestrol, which possess highest estrogenic activity among the known phytoestrogens due to structural similarity to estradiol. Miroestrol was actually the first compound isolated from this plant by a group of German chemists in 1940, but the plant had been mistakenly reported then as Butea Superba. It was later on classified as a new plant called Pueraria mirifica Airy Shaw et Suvatabhandu. The isolation and identification of deoxymiroestrol from the root of Pueraria mirifica has just been reported in the February 2000 issue of the Journal of Natural Products. The authors proposed that since deoxymiroestrol is easily oxidized to miroestrol, deoxymiroestrol, not the previously reported miroestrol, is more likely to be the actual chemical constituent of Pueraria mirifica. However, it is very likely that the two phytoestrogens coexist in the root of this plant. As shown below, the chemical structures of the two compounds are very similar to that of estradiol, the main human estrogen.

In addition to miroestrol and deoxymiroestrol, Pueraria mirifica also contains other chemicals that belong to isoflavone and coumestran groups of phytoestrogens, e.g., Genistein, Daidzein, Daidzin, Genistin, and Coumestrol that are usually found in soybeans. (See table). However, the estrogenic activity of Miroestrol and Deoxymiroestrol is much more potent than that of soy isoflavones.

Table: Chromene, Isoflavonoid and coumestran derivatives in Pueraria mirifica

Chromene	Isoflavones	Isoflavone	Coumestans glycosides
Miroestrol	Daidzein	Daidzin	Coumestrol
Deoxymiroestrol	Genistein	Genistin	Mirificoumestan
	Kawakhurin	Mirificin	Mirificoumestan glycol
	Kawakhurin hydrate	Puerarin	Mirificoumestan hydrate
		Puerarin-6 monoacetate

The results from the studies of researchers and acadamics shows that the selected Pueraria mirifica cultivar contains very high isoflavone contents and showing high antimutagenic effects as well as high killing effects to human mammary cancer cell line. Nowadays nutritionists recommend the consumer to consume isoflavone regularly for the purpose of cancer protection.

Miroestrol and its derivatives are also precious chemicals in the White Kwao Krua which promote estrogenic and mammogenic effects to various tissues and organs such as uterus, ovary and skin.

Soya, the main oriental food and Alfalfa, the western health food products contains lower amount of phytoestrogens especially there is no miroestrol and it’s derivatives. Their benefit to the body is far less than that of Pueraria mirifica. The researches confirm that these chemicals are potent anti-breast cancer , anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome.

Products from Pueraria Mirifica

Breast Serum		Breast Spray		Breast Cream		Breast Mask
Rejuvenile Day Cream		Rejuvenile Night Cream		Firming Facial Mask		Eye Lifting Gel
Rejuvenile Supplement		Menopause Tonic Supplement